Dr Arthur Thompson and his team at the IFR have uncovered new insights into how Salmonella is so well equipped to survive against our bodies’ defences. Building on a comprehensive survey of which genes are turned on in Salmonella, they have now extended the number of start sites defined for Salmonella genes and new non-coding RNAs. This has given the team a better understanding of how regulates its virulence genes associated with its ability to survive and grow inside macrophages.
The data showing the transcriptional start sites in Salmonella has been made accessible with help from IFR bioinformatician John Walshaw at http://opendata.ifr.ac.uk/salseq.
Read more about this on the Gut Health and Food Safety website
Reference: Ramachandran V.K., Shearer N., Thompson A. (2014) The primary transcriptome of Salmonella enterica serovar Typhimurium and its dependence on ppGpp during late stationary phase. PLOS ONE