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Tag Archives | Arjan Narbad

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Fighting bacteria – with viruses

Research published in PLOS Pathogens reveals how viruses called bacteriophages destroy the bacterium Clostridium difficile (C. diff), which is becoming a serious problem in hospitals and healthcare institutes, due to its resistance to antibiotics. The study, by scientists at the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, and the Institute of Food Research could […]

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Transmission Electron Micrograph of normal, wild type (left) and EPS cluster mutant (right) L. johnsonii. The mutant on the right has a much reduced EPS coat

Poultry probiotic’s coat clues to ability to battle bugs

IFR researchers have characterised the coat of a potential poultry probiotic, giving the first clues of how it may be used to exclude pathogenic bacteria from chickens. Lactobacillus johnsonii has previously been shown to exclude Clostridium perfringens from the guts of poultry, opening the door to it being developed as a way of reducing necrotic […]

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C. difficile bacteriophage ΦCD27

Bacteriophages battle superbugs

IFR microbiologists are reinvigorating a way of battling C. difficile infections that they hope will help overcome the growing problem of antibiotic resistant superbugs in hospitals. Our digestive system is home to trillions of bacteria, which are crucial to our overall health, through helping us digest food and battling potentially harmful microbes. When we take […]

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Poultry probiotic cuts its coat to beat bad bacteria

A strain of probiotic bacteria that can fight harmful bacterial infections in poultry has the ability to change its coat, according to new findings from the Institute of Food Research. The probiotic is currently being taken forward through farm-scale trials to evaluate how well it combats Clostridium perfringens – a cause of necrotic enteritis in […]

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The truncated endolysin, tagged with Green fluorescent protein, bound to C. difficile. Image by Kathryn Cross, Imaging Partnership at IFR

Tuning natural antimicrobials to improve their effectiveness at battling superbugs

Ongoing research at IFR, which is strategically funded by BBSRC, is exploring the use of virus-produced proteins that destroy bacterial cells to combat potentially dangerous microbial infections. Bacteriophages produce endolysin proteins that specifically target certain bacteria, and IFR has been studying one that destroys Clostridium difficile, a common and dangerous source of hospital-acquired infections. New […]

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