Tag Archives | Tamas Korcsmáros

Signalling network in colon cancer. Cancer-related proteins are green, first neighbours are orange

Finding new cancer drugs in the neighbourhood

In the search for new drugs to combat cancer, it might be worth calling on the neighbours. Computational biologists have looked at the complex networks of interacting proteins that drive cancer formation, and found that targeting the neighbours of cancer-causing proteins may be just as effective as focusing on the cancer proteins themselves. Cancer is […]

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New study unravels critical genes to understand human diseases and support drug discovery

A network analysis of proteins that are most important in responding to environmental signals highlights potential targets for drugs and provides better information on the genetic basis of diseases.  Throughout evolutionary history, there have been genetic elements that have duplicated – giving rise to genes with different functions. These are called ‘paralogs’. They are able […]

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omnipath

Omnipath sends strong signal

Combining the power of 27 data resources, Omnipath [http://omnipathdb.org] helps researchers see biological signalling pathways with unprecedented accuracy. Developed by researchers in the UK and Germany and published in Nature Methods, OmniPath offers a comprehensive, unified collection of literature-curated signalling pathways based on an analysis of 41 000 scientific papers. All the functions happening in […]

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Schematic diagram of the steps of autophagy
Figure by Meléndez, A. and Levine, B. Autophagy in C. elegans (August 24, 2009), WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.147.1, http://www.wormbook.org.[CC by 2.5]

Autophagy – A review of techniques

The third edition of “Guidelines for the use and interpretation of assays for monitoring autophagy” was recently published in the leading journal Autophagy,featuring TGAC’s Autophagy Regulatory Network resourceand co-authored by Dr Tamas Korcsmaros, Computational Biology Fellow at The Genome Analysis Centre (TGAC) and Institute of Food Research (IFR). In this comprehensive review with over 2,450 […]

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New software being developed to help answer complex biological questions

A Norwich Research Park translational grant will help in the development of a multi-functional data integration software tool to improve metadata and network analysis efficiency. This novel software will provide a comprehensive systems biology platform for the integration of diverse datasets. The bespoke Omix Navigator will be available from spring 2016. In bioscience, thousands of […]

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Tamás Korcsmáros

New resource to study the mechanism and regulation of autophagy to fight human disease

Tamás Korcsmáros, Computational Biology Fellow at The Genome Analysis Centre (TGAC) and the Institute of Food Research (IFR), has led the development of an Autophagy Regulatory Network (ARN) online resource to further research in this human cellular process, to help combat cancer and neurodegenerative diseases. Autophagy, derived from the Greek term for ‘eating of self’, […]

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Tamás Korcsmáros

Computational Biologist joins IFR and TGAC to better understand gut diseases.

Tamás Korcsmáros has been appointed as a Computational Biology Fellow at The Genome Analysis Centre and in the Institute of Food Research (IFR), from 17 March 2014. Tamás’ joint appointment builds on TGAC’s computational biology strengths and the IFR’s expertise in gut bacteria research to better understand how certain diseases of the gut develop. During […]

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